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Rifaximin plus cefotaxime versus cefotaxime alone in treatment of spontaneous bacterial peritonitis in patients with cirrhosis

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dc.contributor.author Muhammad, Asmaa N. ; El-Samman, Mahmoud K. ; Zaghloul, Amr M. ; Muhammad, Hamida H. ; Muhammad, Walaa E.
dc.date.accessioned 2019-12-23T09:19:25Z
dc.date.available 2019-12-23T09:19:25Z
dc.date.issued 20180900
dc.identifier.issn 1110-7782
dc.identifier.uri http://beta.space.iknito.com/handle/ekb/116926
dc.description.abstract Background/purpose of the study Spontaneous bacterial peritonitis (SBP) is a cause of significantly higher morbidity and mortality in patients with cirrhosis. This study was conducted to assess the effect of adding rifaximin to cefotaxime in treatment of SBP. Materials and methods The study was a prospective one that involved 98 patients with cirrhosis with SBP, who were divided randomly into two equal groups. Patients in group I received cefotaxime, whereas patients in group II received a combination of cefotaxime and rifaximin. Patients were evaluated clinically, and diagnostic aspiration was repeated on the third day of antibiotic therapy. Results Both groups showed significant reduction in white blood cells on the third day compared with the first day (P<0.0001). Polymorphonuclear leukocyte count in ascetic fluid in both groups showed significant reduction on the third day compared with the first day, and the reduction was statistically significant in group II compared with group I (P<0.0001). One the third day of therapy, serum creatinine levels in group I and group II were 1.61±0.19 and 1.28±0.37, respectively. Both groups showed significant decrease in serum creatinine level. The reduction in group II compared with group I was statistically significant, with P value less than 0.0001. Conclusion Rifaximin plus cefotaxime showed some favorable effects in treatment of SBP than cefotaxime alone. However, the clinical effects of these effects need to be clarified in further studies. en
dc.language English
dc.publisher Wolters Kluwer Medknow, Mumbai (IND)
dc.subject Cefotaxime ; Liver cirrhosis ; Rifaximin ; Spontaneous bacterial peritonitis
dc.title Rifaximin plus cefotaxime versus cefotaxime alone in treatment of spontaneous bacterial peritonitis in patients with cirrhosis en
dc.identifier.doi 10.4103/ejim.ejim_19_18
local.pagination 6
local.pages 154-159
local.numberOfTables 3
local.numberOfReferences 27
local.affiliation Sohag Univ. (EGY). Fac. of Med. ; Sohag Univ. (EGY). Fac. of Med. ; Sohag Univ. (EGY). Fac. of Med. ; Sohag Univ. (EGY). Fac. of Med. ; Sohag Univ. (EGY). Fac. of Med.
local.organization Egyptian Society of Internal Med., Cairo (EGY)
local.journalTitle Journal of Medicine in Scientific Research
local.volume 3
local.issue n3


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